Planes, Trains, and Automobiles (1987)

Steve Martin and John Candy get stuck going cross-country together (presumably via plane, train, and automobile). At one point they share a bed in a hotel and John Candy says he has his hands between two pillows and Steve Martin says, "THOSE AREN'T PILLOWS!" (Or, wait, probably it's Steve Martin who has his hands in John Candy's ass, right?) Also they stand holding suitcases, hitchhiking. I think both of the things I remember about this movie were in the trailer.

Totally forgot they're transporting a 12-year-old Swedish vampire.